Tae Young Jang
Inha University, South Korea
Title: Nasal provocation test: Allergen provocation and cold air provocation test
Biography
Biography: Tae Young Jang
Abstract
Nasal Provocation Test (NPT) is an ideal test for diagnosing Allergic Rhinitis (AR), since the target organ, the nasal cavity itself, is directly provoked by the causative allergen. In spite of its usefulness, NPT has not been widely accepted in clinical practice, because of its lack of standardized method and diagnostic criteria. The nonspecific Nasal Hyper-Reactivity (NHR) could be defined as hyper-responsiveness of the nasal cavity induced by nonspecific, non-allergenic stimuli. Cold Dry Air (CDA) provocation test is one of the provocative protocols designed to detect and evaluate this NHR. It has been accepted that CDA provocation is superior to other protocols in detecting NHR. However, there had been still very few studies about its clinical application. This lecture will introduce our method of NPT using intranasal spray of house dust mite allergen extract. This lecture will also discuss the association between NPT and skin prick test, and the proposed diagnostic criteria of AR using acoustic rhinometry in our large-population based study. This lecture will introduce CDA machinery we developed, and discuss its usefulness in detecting and evaluating NHR. This lecture will also cover the diagnostic criteria of NHR using CDA provocation and acoustic rhinometry. Finally, our Subjective Cold Hyper-responsiveness (SCH) grade would be introduced, which was proved to correlate well with the actual result of CDA provocation test.